The Faustman Lab at Mass General | Academic Publications

Academic Publications

Selected Faustman Lab publications, including PDFs of journal articles and links to abstracts, are included here.

Faustman DL. EBV infection and anti-CD3 treatment for Type 1 diabetes: bad cop, good cop? Expert Rev Clin Immunol. 2013; 9(2): 95–97. Full Paper
Faustman DL, Wang L, Okubo Y, Burger D, Ban L, et al. Proof-of-Concept, Randomized, Controlled Clinical Trial of Bacillus-Calmette-Guerin for Treatment of Long-Term Type 1 Diabetes. PLoS ONE 2012;7(8): e41756. Full Paper
Wang L, Fraser Loverjoy N, Faustman DL. Persistence of Prolonged C-peptide Production in Type 1 Diabetes as Measured With an Ultrasensitive C-peptide Assay. Diabetes Care 2012;35:1-6. Full Paper
Burger DE, Wang L, Ban L, Okubo Y, Kühtreiber WM, et al. Novel Automated Blood Separations Validate Whole Cell Biomarkers. PLoS ONE. 2011; 6(7): e22430. Full Paper
Denise L. Faustman, Miriam Davis. Stem cells in the spleen: Therapeutic potential for Sjogren’s syndrome, typeI diabetes, and other disorders.Int J Biochem Cell Biol(2010). Full Paper
Faustman D, Davis M. TNF receptor 2 pathway: drug target for autoimmune diseases.Nat Rev Drug Discov. 2010 Jun;9(6):482-93. Epub 2010 May 21. PMID: 20489699. Full Paper
Morawietz L, Martinez-Gamboa L, Scheffler S, Hausdorf G, Dankof A, Kuckelkorn U, Doerner T, Egerer K, Burmester GR, Faustman DL, Feist E. Expression of proteasomal immunosubunit ß1i is dysregulated in inflammatory infiltrates of minor salivary glands in Sjögren’s syndrome. J Rheumatol 2009; 36:2694-703. Full Paper
Dieguez-Acuna F, Kodama S, Okubo Y, Paz AC, Gygi SP, Faustman DL. Proteomics identifies multipotent and low oncogenic risk stem cells of the spleen. Int J Biochem Biol. 2009 Full Paper
Faustman DL and Davis M. The primacy of CD8 T lymphocytes in type 1 diabetes and implications for therapies. J Mol Med 2009; 87:1173-8. Full Paper

Faustman D, Davis M. Immunotherapy for Type 1 Diabetes Takes Aim at Autoreactive T Cells. Rev Endocrinol. 2009. Full Paper
Faustman DL. Immunotherapy on trial for new onset type 1 diabetes. NEJM 2008; 359:1956-8. Full Paper.

Ban L, Zhang J, Wang L, Kuhtreiber W, Burger D, and Faustman DL. Selective death of autoreactive T cells in human diabetes by TNF or TNF receptor 2 agonism. Proceedings of the National Academy of Sciences; 13,644-13,649. Full Paper
Liston A. Autoimmunity: Beyond the immune system. Immunol Cell Biol 2008; 1-2. Full Paper
Lonyai A, Kodama S, Burger D, Faustman DL. Fetal Hox11 expression patterns predict defective target organs: a novel link between developmental biology and autoimmunity. Immunol Cell Biol 2008; 86:301-9. Full Paper
Lonyai A, Kodama S, Burger D, Davis M, Faustman DL. The promise of Hox11+ stem cells of the spleen for treating autoimmune diseases. Horm Metab Res 2008; 40:137-46. Full Paper
Tran SD, Kodama S, Lodde BM, Szalayova I, Key S, Khalili S, Faustman DL, Mezey E. Reversal of Sjogren's-like syndrome in non-obese diabetic mice. Ann Rheum Dis 2007; 66:812-4. Full Paper
Dieguez-Acuna FJ, Gygi SP, Davis M, Faustman DL. Splenectomy: a new treatment option for ALL tumors expressing Hox-11 and a means to test the stem cell hypothesis of cancer in humans. Leukemia 2007; 21;2192-234. Full Paper
Faustman DL. Reversal of type 1 diabetes in mice. N Engl J Med 2007; 356:311-2. Full Paper
Faustman DL. Permanent reversal of diabetes in NOD mice. Science 2007; 317:196. Full Paper
Faustman DL, Tran SD, Kodama S, Lodde BM, Szalayova I, Key S, Toth ZE, Mezey E. Comment on papers by Chong et al, Nishio et al, and Suri et al on diabetes reversal in NOD mice. Science 2006; 314:1243. Full Paper.
Faustman D. Search for cure moves forward despite controversy interview by Ho Spencer. Nephrol News Issues 2006; 20:24, 26. Full Paper.

Dale E, Davis M, Faustman DL. A role for transcription factor NF-kB in autoimmunity: possible interactions of genes, sex, and the immune response. Adv Physiol Edu 2006; 30:152-8. Full Paper
Kodama S, Davis M, Faustman DL. Regenerative medicine: a radical reappraisal of the spleen. Trends Molec Med 2005; 11:271-6. Full Paper
Kodama S, Davis M, Faustman DL. Diabetes and Stem Cell Researchers Turn to the Lowly Spleen. Science SAGE 2005; pe2. Full Paper
Dieguez-Acuna FJ, Gerber SA, Kodama S, Elias JE, Beausoleil SA, Faustman D, Gygi SP. Characterization of mouse spleen cells by subtractive proteomics. Molec Cell Proteomics 2005: 4:1459-70. Full Paper
Kuhtreiber WM, Kodama S, Burger DE, Dale EA, Faustman DL. Methods to characterize lymphoid apoptosis in a murine model of autoreactivity. J Immunol Meth 2005; 30:137-50. Full Paper
Kodama S, Davis M, Faustman DL. The therapeutic potential of tumor necrosis factor for autoimmune disease: a mechanistically based hypothesis. Cell Molec Life Sci 2005; 62: 1850-62. Full Paper
Kodama S, Faustman DL. Routes to regenerating islet cells: stem cells and other biological therapies for type 1 diabetes. Pediatric Diabetes 2004; 5:38-44. Full Paper
Abraham EJ, Kodama S, Lin JC, Ubeda M, Faustman DL, Habener JF. Human pancreatic islet-derived progenitor cell engraftment in immunocompetent mice. Am J Pathol. 2004 Mar;164(3):817-30. Abstract
Kuhtreiber WM, Hayashi T, Dale EA, Faustman DL. Central role of defective apoptosis in autoimmunity. J Mol Endocrinol. 2003 Dec;31(3):373-99. Abstract
Hayashi T, Faustman DL. Role of defective apoptosis in type 1 diabetes and other autoimmune diseases. Recent Prog Horm Res. 2003;58:131-53. Abstract
Penfornis A, Yan G, Shi L, Faustman DL. Polymorphisms of human TAP2 detected by denaturing gradient gel electrophoresis. Hum Immunol. 2003 Jan;64(1):156-67. Abstract
Yan G, Shi L, Penfornis A, Faustman DL. Impaired processing and presentation by MHC class II proteins in human diabetic cells. J Immunol. 2003;170:520-7. Abstract
Kodama S, Kuhtreiber W, Fujimura S, Dale EA, Faustman DL. Islet regeneration during the reversal of autoimmune diabetes in NOD mice. Science. 2003;302:1223-7. Abstract
Hayashi T, Faustman DL. Development of spontaneous uterine tumors in low molecular mass polypeptide-2 knockout mice. Cancer Res. 2002 Jan 1;62(1):24-7. Abstract
Faustman DL, Pedersen RL, Kim SK, Lemischka IR, McKay RD. Cells for repair: breakout session summary. Ann NY Acad Sci 2002; 961:45-7. Abstract.
Faustman DL. Reversal of established autoimmune diabetes by in situ beta-cell regeneration. Ann NY Acad Sci 2002; 961:40. Abstract.
Penfornis A, Tuomilehto-Wolf E, Faustman DL, Hitman GA, DiMe (Childhood Diabetes in Finland) Study Group. Hum Immunol 2002; 63:61-70. Abstract.

Hayashi T, Faustman DL. Selected contribution: Association of gender-related LMP2 inactivation with autoimmune pathogenesis. J Appl Physiol. 2001 Dec;91(6):2804-15. Abstract
Ryu S, Kodama S, Ryu K, Schoenfeld DA, Faustman DL. Reversal of established autoimmune diabetes by restoration of endogenous ÃŸ-cell function. J Clin Invest. 2001; 108:63-72. Abstract
Hayashi T, Faustman DL. Implications of altered apoptosis in diabetes mellitus and autoimmune disease. Apoptosis. 2001 Feb-Apr;6(1-2):31-45. Abstract
Lee ML, Schoenfeld D, Wang X, Penfornis A, Faustman D. Bayesian analysis of case control polygenic etiology studies with missing data. Biostatistics 2001; 2:309-22. Abstract.

Hayashi T, Faustman D. Essential role of human leukocyte antigen-encoded proteasome subunits in NF-kappaB activation and prevention of tumor necrosis factor-alpha-induced apoptosis. J Biol Chem. 2000 Feb 18; 275(7):5238-47. Abstract
Hayashi T, Kodama S, Faustman D. Reply to 'LMP2 expression proteasome activity in NOD mice. Nature Med. 2000; 6:1065-66. Abstract
Hayashi T, Faustman D. Defective function of the proteasome in autoimmunity: involvement of impaired NF-kappaB activation. Diabetes Technol Ther. 2000 Autumn;2(3):415-28. Abstract
Hayashi T, Faustman D. A role for NF-kappaB and the proteasome in autoimmunity. Arch Immunol Ther Exp 2000; 48:353-65. Abstract.
Hayashi T, Faustman D. The role of the proteasome in autoimmunity. Diabetes Metab Res Rev 2000; 16:325-37. Abstract.
Yan G, Schoenfeld D, Penney C, Hurxthal K, Taylor AE, Faustman D. Identification of premature ovarian failure patients with underlying autoimmunity. J Womens Health Gend Based Med 2000; 9:275-87. Abstract.

Hayashi T, Faustman D. NOD mice are defective in proteasome production and activation of NF-kappaB. Mol Cell Biol. 1999 Dec; 19(12):8646-59. Abstract
Faustman D. On the periphery: Nature questions the role of women in science. J Womens Health Gend Based Med 1999; 8:1009-10. Abstract.
Yan G, Shi L, Faustman D. Novel splicing of the human MHC-encoded peptide transporter confers unique properties. J Immunol 1999; 162:852-9. Abstract.
Fu Y, Yan G, Shi L, Faustman D. Antigen processing and autoimmunity. Evaluation of mRNA abundance and function of HLA-linked genes. Ann NY Acad Sci 1998; 842:138-55. Abstract.

Yan G, Shi L, Fu Y, Wang X, Schoenfeld D, Ma L, Penfornis A, Gebel H, Faustman DL. Screening of the TAP1 gene by denaturing gradient gel electrophoresis in insulin-dependent diabetes mellitus: detection and comparison of new polymorphisms between patients and controls. Tissue Antigens. 1997 Dec;50(6):576-85. Abstract
Faustman DL. Gender is important: lessons in autoimmunity. J Womens Health. 1997 Oct;6(5):521-2. Abstract
Lernmark A, Eisenbarth G, Ducat L, Erlich HA, Faustman D, Maclaren NK, Ott J, Permutt MA, She JX, Todd J. Am J Hum Genet 1997; 61:778-9. Abstract.

Yan G, Fu Y, Faustman DL. Reduced expression of Tap1 and Lmp2 antigen-processing genes in the nonobese diabetic (NOD) mouse due to a mutation in their shared bidirectional promoter. J Immunol. 1997 Sep 15;159(6):3068-80. Abstract
Tambur AR, Foster P, Mellins E, Cresswell P, Faustman D, Gebel HM. Ultraviolet B irradiation reduces the surface expression of conformationally correct class I and II histocompatibility antigens. Transplant Proc 1997; 29:2689-91. Abstract.
Shi L, Yan G, Fu Y, Ma L, Penfornis A, Faustman D. Human TAP1 polymorphisms detected by denaturing gradient gel electrophoresis. Tissue Antigens 1997; 49:421-6. Abstract.

Ma L, Penfornis A, Wang X, Schoenfeld D, Tuomilehto-Wolf E, Metcalfe K, Hitman G, Faustman D. Evaluation of TAP1 polymorphisms with insulin dependent diabetes mellitus in Finnish diabetic patients. The Childhood Diabetes in Finland (DiMe) Study Group. Hum Immunol 1997; 53:159-66. Abstract.
Pinies JA, Fu Y, Vazquez JA, Faustman D. New monoclonal antibody diagnostic reagents for type 1 diabetes: differential lymphocyte surface antigen expression related to disease. Diabetes 1997; 46:363-71. Abstract.

Huang R, Guo J, Li X, Faustman DL. Elimination of self-peptide major histocompatibility complex class I reactivity in NOD and beta 2-microglobulin-negative mice. Diabetes. 1995 Sep;44(9):1114-20. Abstract
Li F, Linan MJ, Stein MC, Faustman DL. Reduced expression of peptide-loaded HLA class I molecules on multiple sclerosis lymphocytes. Ann Neurol. 1995 Aug;38(2):147-54. Abstract
Wang F, Li X, Annis B, Faustman DL. Tap-1 and Tap-2 gene therapy selectively restores conformationally dependent HLA Class I expression in type I diabetic cells. Hum Gene Ther. 1995 Aug;6(8):1005-17. Abstract
Faustman DL. Altered MHC class I expression: a role for transplantation and IDDM autoimmunity. Diabetes Metab Rev. 1995 Apr;11(1):1-19. Abstract
Faustman D. Strategies for circumventing transplant rejection: modification of cells, tissues and organs. Trends Biotechnol 1995; 13:100-5. Abstract.

Vidal-Puig A, Faustman DL. Tolerance to peripheral tissue is transient and maintained by tissue-specific class I expression. Transplant Proc. 1994 Dec;26(6):3314-6. Abstract
Li F, Guo J, Fu Y, Yan G, Faustman D. Abnormal class I assembly and peptide presentation in the nonobese diabetic mouse. Proc Natl Acad Sci USA. 1994;91:11128-32. Abstract
Faustman DL. Occult CD45 T cell developmental defect in type 1 diabetes. Diabete Metab. 1993 Sep-Oct;19(5):446-57. Abstract
Li X, Golden J, Faustman DL. Faulty major histocompatibility complex class II I-E expression is associated with autoimmunity in diverse strains of mice. Autoantibodies, insulitis, and sialadenitis. Diabetes. 1993 Aug;42(8):1166-72. Abstract
Fu Y, Nathan DM, Li F, Li X, Faustman DL. Defective major histocompatibility complex class I expression on lymphoid cells in autoimmunity. J Clin Invest. 1993;91:2301-7. Abstract
Li X, Faustman D. Use of donor beta 2-microglobulin deficient transgenic mouse liver cells for isografts, allografts and xenografts. Transplantation 1993; 55:940-6. Abstract.
Hardiman O, Faustman D, Li X, Sklar RM, Brown RH Jr. Expression of major histocompatibility complex antigens in cultures of clonally derived human myoblasts. Neurology 1993; 43:604-8. Abstract.
Faustman D. Mechanisms of autoimmunity in type 1 diabetes. J Clin Immunol 1993; 13:1-7. Abstract.

Faustman DL. MHC class I and autoimmune diabetes. Biomed Pharmacother. 1993;47(1):3-10. Abstract
Faustman D. Faulty major histocompatibility complex class I function linked to autoimmune diabetes. Transplant Proc. 1992; 24:2874-6. Abstract.
Faustman D, Coe C. Xenograft acceptance by masking donor antigens. Transplant Proc. 1992; 24:2854-5. Abstract.
Faustman D, Li X, Lin HY, Huang R, Guo J. Response. Science 1992; 256:1830-31. Abstract.

Lanza RP, Butler DH, Borland KM, Harvey JM, Faustman DL, Solomon BA, Muller TE, Rupp RG, Maki T, Monaco AP, et al. Successful xenotransplantation of a diffusion-based biohybrid artificial pancreas: a study using canine, bovine, and porcine islets. Transplant Proc. 1992 Apr;24(2):669-71. Abstract
Faustman D, Coe C. Prevention of xenograft rejection by masking donor HLA class I antigens. Science. 1991 Jun;252(5013):1700-2. Abstract
Faustman D, Li XP, Lin HY, Fu YE, Eisenbarth G, Avruch J, Guo J. Linkage of faulty major histocompatibility complex class I to autoimmune diabetes. Science. 1991 Dec 20;254(5039):1756-61. Abstract
Lanza RP, Butler DH, Borland KM, Staruk JE, Faustman DL, Solomon BA, Muller TE, Rupp RG, Maki T, Monaco AP, et al. Xenotransplantation of canine, bovine, and porcine islets in diabetic rats without immunosuppression. Proc Natl Acad Sci U S A. 1991 Dec 15;88(24):11100-4. Abstract
Faustman D, Schoenfeld D, Ziegler R. T lymphocyte changes linked to autoantibodies. Association of insulin autoantibodies with CD4+CD45R+ lymphocyte subpopulation in prediabetic subjects. Diabetes 1991; 40:590-7. Abstract.
Faustman D, Eisenbarth G, Breitmeyer J. Analysis of T lymphocyte subsets in all stages of diabetes. J Autoimmun 1990; 3:111-6. Abstract.
Faustman D, Eisenbarth G, Daley J, Breitmeyer J. Abnormal T-lymphocyte subsets in type 1 diabetes. Diabetes 1989; 38:1462-8. Abstract.

Breitmeyer JB, Faustman DL. Sheep erythrocyte rosetting induces multiple alterations in T lymphocyte function: inhibition of T cell receptor activity and stimulation of T11/CD2. Cell Immunol. 1989 Oct 1;123(1):118-33. Abstract
Faustman DL, Hauptfeld V, Davie JM, Lacy PE. Prolonged survival of donor skin grafts on mice bearing established islet of Langerhans transplants. Transplantation. 1986 Aug;40(2):216-8. Abstract
Rossini AA, Faustman D, Woda BA, Like AA, Szymanski I, Mordes JP. Lymphocyte transfusions prevent diabetes in the Bio-Breeding/Worcester rat. J Clin Invest 1984; 74:39-46. Abstract.

Faustman DL, Steinman RM, Gebel HM, Hauptfeld V, Davie JM, Lacy PE. Prevention of rejection of murine islet allografts by pretreatment with anti-dendritic cell antibody. Proc Natl Acad Sci U S A. 1984 Jun;81(12):3864-8. Abstract
Faustman D, Kraus P, Lacy PE, Finke EH, Davie JM. Survival of heart allografts in nonimmunosuppressed murine recipients by pretreatment of the donor tissue with anti-Ia antibodies. Transplantation 1982; 34:302-5. Abstract.
Faustman D, Lacy PE, Davie JM. Transplantation without immunosuppression. Diabetes 1982; 31:11-6. Abstract.
Faustman D, Lacy P, Davie J, Hauptfeld V. Prevention of allograft rejection by immunization with donor blood depleted of Ia-bearing cells. Science 1982; 217:157-8. Abstract.
Faustman D, Hauptfeld V, Lacy P, Davie J. Demonstration of active tolerance in maintenance of established islet of Langerhans allografts. PNAS 1982; 79:4153-5. Abstract.