Publications
The benefits of clustering in TNF receptor superfamily signaling
Eva S. Vanamee and Denise L. Faustman
Frontiers in Immunology August 2023
Bacille Calmette Guerin (BCG) and prevention of types 1 and 2 diabetes: Results of two observational studies
Hans F. Dias, Yoshihiko Mochizuki, Willem M. Kühtreiber, Hiroyuki Takahashi, Hui Zheng, Denise L. Faustman
PLOS ONE January 2023
An Old TB Vaccine Might Help Stave Off Diabetes, Cancer Alzheimer’s, and More
Viviane Callier
Scientific American January 2023
TNFR2 antagonistic antibody induces the death of tumor infiltrating CD4+Foxp3+ regulatory T cells
Tianzhen He,Yibo Chen, De Yang, Md Sahidu, Islam1, Chon‑Kit Chou, Jiarui Liu, Denise L. Faustman, Joost J. Oppenheim, Xin Chen
Cellular OncologyNovember 2022
BCG vaccinations drive epigenetic changes to the human T cell receptor: Restored expression n type 1 diabetes
Hiroyuki Takahashi, Willem M. Kühtreiber, Ryan C. Keefe, Amanda H. Lee, Anna Aristarkhova, Hans F. Dias, Nathan Ng, Kacie J. Nelson, Stephanie Bien, Danielle Scheffey, Denise L. Faustman
Science Advances November 2022
Multiple BCG vaccinations for prevention of COVID-19 and other infectious diseases in Type 1 diabetes
Denise L. Faustman, Amanda Lee, Emma R. Hostetter, Anna Aristarkhova, Nathan C. Ng, Gabriella F. Shpilsky, Lisa Tran, Grace Wolfe, Hiroyuki Takahashi, Hans F. Dias, Joan Braley, Hui Zheng, David A. Schoenfeld, Willem M. Kuhtreiber
Cell Reports Medicine August 2022
The Roles of TNFR2 Signaling in Cancer Cells and the Tumor Microenvironment and the Potency of TNFR2 Targeted Therapy
Hiroyuki Takahashi, Gumpei Yoshimatsu, and Denise Louise Faustman
American Diabetes Association Annual Scientific Sessions June 2022
2022 Update on the BCG Clinical Trial Programs in Advanced Type 1 Diabetes
W.M. Kühtreiber, H.F. Dias, E. Hostetter, A.H. Lee, N. Ng, G. Wolfe, A. Aristarkhova, J. Bradley, H. Zheng, & D.L Faustman
American Diabetes Association Annual Scientific Sessions June 2022
Underlying T Cell Receptor Methylation Defects in Type 1 Diabetes Associated with Quantitative Defects
H. Takahashi, W.M. Kühtreiber, A.H. Lee, A. Aristarkhova, H.F. Dias, N. Ng, S. Bien, D. Scheffey, & D.L Faustman
American Diabetes Association Annual Scientific Sessions June 2022
Signal Amplification in Highly Ordered Networks Is Driven by Geometry
Éva S. Vanamee, Gábor Lippner and Denise L. Faustman
Cells January 13, 2022
A TNFR2 antibody by countering immunosuppression cooperates with HMGN1 and R848 immune stimulants to inhibit murine colon cancer
Mengmeng Jiang, Jia Liu, De Yang, Debra Tross, Ping Li, Fengyang Chen, Md Masud Alam, Denise L. Faustman, Joost J. Oppenheim, Xin Chen
International Immunopharmacology November 15 2021
Bacillus Calmette-Guerin ’s beneficial impact on glucose metabolism: Evidence for broad based applications
Gabriella F. Shpilsky, Hiroyuki Takahashi, Anna Aristarkhova, Michele Weil, Nathan Ng, Kacie J. Nelson, Amanda Lee, Hui Zheng, Willem M. Kuhtreiber, and Denise L. Faustman
iSciene October 22 2021
BCG therapy is associated with long-term, durable induction of Treg signature genes by epigenetic modulation
Ryan C. Keefe, Hiroyuki Takahashi, Lisa Tran, Kacie Nelson, Nathan Ng,
Willem M. Kühtreiber & Denise L. Faustman
Scientific Reports July 2021
Epigenetic changes related to glucose metabolism in type 1 diabetes after BCG vaccinations: A vital role for KDM2B
Hans F. Dias, Willem M. Kühtreiber, Kacie J. Nelson, Nathan C. Ng, Hui Zheng, Denise L. Faustman
Vacine May 2021
A novel TNFR2 agonist antibody expands highly potent regulatory T cells
Heather Torrey, Willem M. Kühtreiber, Yoshiaki Okubo, Lisa Tran, Katherine Case, Hui Zheng, Eva Vanamee, Denise L. Faustman
Science Signaling December 8 2020
FOCIS 2020 Conference
October 28 – 31 2020
TNFR2 blockade alone or in combination with PD-1 blockade shows therapeutic efficacy in murine cancer models
Katherine Case, Lisa Tran, Michael Yang, Hui Zheng, Willem M. Kuhtreiber and Denise L. Faustman
J Leukoc Biol May 2020
BCG Vaccinations Upregulate Myc, a Central Switch for Improved Glucose Metabolism in Diabetes
Willem M. Kuhtreiber, Hiroyuki Takahashi, Ryan C. Keefe, Yaerin Song, Lisa Tran, Trevor G. Luck,Gabriella Shpilsky, Louisa Moore, Sarah M. Sinton, Jessica C. Graham, and Denise L. Faustman
iScience May 22, 2020
Optimizing TNFR2 Antagonism for Immunotherapy with Tumor Microenvironment Specificity
Michael Yang, Lisa Tran, Heather Torrey, Yaerin Song, Haley Perkins, Katherine Case, Hui Zheng, Hiroyuki Takahashi, Willem M. Kuhtreiber, Denise L. Faustman
Journal of Leukocyte Biology March 2020
Benefits of BCG-induced Metabolic Switch from Oxidative Phosphorylation to Aerobic Glycolysis in Autoimmune and Nervous System Diseases
Denise Faustman
Journal of Internal Medicine March 2020
On the TRAIL of Better Therapies: Understanding TNFRSF Structure-Function
Éva S. Vanamee and Denise L. Faustman
Cells March 2020
BCG Therapy for Type 1 Diabetes: Restoration of Balanced Immunity and Metabolism
Willem M. Kühtreiber and Denise L. Faustman
Cell Press February 2019
Bridging the gap between vaccination with Bacille Calmette-Gue´ rin (BCG) and immunological tolerance: the cases of type 1 diabetes and multiple sclerosis
Giovanni Ristori, Denise Faustman, Giuseppe Matarese,
Silvia Romano and Marco Salvetti
CurrentOpinionImmunology December 2018
Intrinsic TNFR2 signaling in T regulatory cells provides protection in CNS autoimmunity
Kamar-Sulu N. Atretkhany, Ilgiz A. Mufazalov, Josefine Dunst, Anna Kuchmiy, Violetta S. Gogoleva,David Andruszewski, Marina S. Drutskaya, Denise L. Faustman, Marius Schwabenland, Marco Prinz,Andrey A. Kruglov, Ari Waisman, and Sergei A. Nedospasov.
PNAS November 2018
Targeted killing of TNFR2-expressing tumor cells and Tregs by TNFR2 antagonistic antibodies in advanced Sézary syndrome
H Torrey, M Khodadoust, L Tran, D Baum, A Defusco, Y H Kim, D L Faustman
Nature Leukemia October 24 2018
Long-term Reduction in Hyperglycemia in Advanced Type 1 Diabetes: The Value of Induced Aerobic Glycolysis with BCG Vaccinations
Willem M. Kühtreiber, Lisa Tran, Taesoo Kim, Michael Dybala, Brian Nguyen, Sara Plager, Daniel Huang, Sophie Janes, Audrey Defusco, Danielle Baum, Hui Zheng & Denise L. Faustman
npj Vaccines June 21 2018
Structural Principles of Tumor Necrosis Factor Superfamily Signaling
Vanamee ÉS, Faustman DL.
Sci Signal. 2018 Jan 2;11(511).
pii: eaao4910. doi: 10.1126/scisignal.aao4910. Review.
PMID:29295955
TNFR2: A Novel Target for Cancer Immunotherapy
Vanamee ÉS, Faustman DL.
Trends Mol Med. 2017 Nov;23(11):1037-1046.
doi: 10.1016/j.molmed.2017.09.007.
Epub 2017 Oct 12. Review.
PMID: 29032004
TNF, TNF Inducers, and TNFR2 Agonists: A New Path to Type 1 Diabetes Treatment
Faustman DL.
Diabetes Metab Res Rev. 2018 Jan;34(1).
doi: 10.1002/dmrr.2941.
Epub 2017 Sep 29. Review.
PMID: 28843039
Targeting TNFR2 with Antagonistic Antibodies Inhibits Proliferation of Ovarian Cancer Cells and Tumor-associated Tregs
Torrey H, Butterworth J, Mera T, Okubo Y, Wang L, Baum D, Defusco A, Plager S, Warden S, Huang D, Vanamee E, Foster R, Faustman DL.
Sci Signal.2017 Jan 17;10(462).
pii: eaaf8608. doi: 10.1126/scisignal.aaf8608.
PMID: 28096513
Treg Activation Defect In Type 1 Diabetes: Correction With TNFR2 Agonism
Okubo Y, Torrey H, Butterworth J, Zheng H, Faustman DL.
Clin Transl Immunology. 2016 Jan 8;5(1):e56.
doi: 10.1038/cti.2015.43.
eCollection 2016 Jan.
PMID: 26900470 Free PMC Article
Strategic Internal Covalent Cross-linking of TNF Produces A Stable TNF Trimer with Improved TNFR2 Signaling
Ban L, Kuhtreiber W, Butterworth J, Okubo Y, Vanamee ÉS, Faustman DL.
Mol Cell Ther. 2015 Aug 12;3:7.
doi: 10.1186/s40591-015-0044-4.
eCollection 2015.
Low Levels of C-peptide Have Clinical Significance for Established Type 1 Diabetes
Kuhtreiber WM, Washer SL, Hsu E, Zhao M, Reinhold P 3rd, Burger D, Zheng H, Faustman DL.
Diabet Med. 2015 Oct;32(10):1346-53.
doi: 10.1111/dme.12850.
Epub 2015 Aug 16.
PMID: 26172028 Free PMC Article
Removal of Donor Human Leukocyte Antigen Class I Proteins With Papain: Translation for Possible Whole Organ Practices
Mera T, Faustman DL.
Transplantation. 2015 Apr;99(4):724-30.
doi: 10.1097/TP.0000000000000436.
PMID: 25340603
TNF Receptor 2 and Disease: Autoimmunity and Regenerative Medicine
Faustman DL, Davis M.
Front Immunol. 2013 Dec 23;4:478.
doi: 10.3389/fimmu.2013.00478.
PMID: 24391650 Free PMC Article
Homogeneous Expansion Of Human T-regulatory Cells Via Tumor Necrosis Factor Receptor 2
Okubo Y, Mera T, Wang L, Faustman DL.
Sci Rep. 2013 Nov 6;3:3153.
doi: 10.1038/srep03153.
PMID: 24193319 Free PMC Article
Why Were We Wrong For So Long? The Pancreas Of Type 1 Diabetic Patients Commonly Functions for Decades
Faustman DL. Diabetologia.
2014 Jan;57(1):1-3.
doi: 10.1007/s00125-013-3104-9.
Epub 2013 Nov 5.
PMID: 24190583
Proof-of-concept, Randomized, Controlled Clinical Trial Of Bacillus-Calmette-Guerin For Treatment Of Long-term Type 1 Diabetes
Faustman DL, Wang L, Okubo Y, Burger D, Ban L, Man G, Zheng H, Schoenfeld D, Pompei R, Avruch J, Nathan DM.
PLoS One. 2012;7(8):e41756.
doi: 10.1371/journal.pone.0041756.
Epub 2012 Aug 8.
PMID: 22905105 Free PMC Article
Persistence of Prolonged C-peptide Production In Type 1 Diabetes As Measured With An Ultrasensitive C-peptide Assay
Wang L, Lovejoy NF, Faustman DL.
Diabetes Care. 2012 Mar;35(3):465-70.
doi: 10.2337/dc11-1236.
PMID: 22355018 Free PMC Article
Novel Automated Blood Separations Validate Whole Cell Biomarkers
Burger DE, Wang L, Ban L, Okubo Y, Kühtreiber WM, Leichliter AK, Faustman DL.
PLoS One. 2011;6(7):e22430.
doi: 10.1371/journal.pone.0022430. Epub 2011 Jul 22.
PMID: 21799852 Free PMC Article
Stem Cells In The Spleen: Therapeutic Potential For Sjogren’s Syndrome, Type I Diabetes, And Other Disorders
Faustman DL, Davis M.
Int J Biochem Cell Biol. 2010 Oct;42(10):1576-9.
doi: 10.1016/j.biocel.2010.06.012.
Epub 2010 Jun 18. Review.
PMID: 20601088 Free PMC Article
The Primacy Of CD8 T Lymphocytes In Type 1 Diabetes And Implications For Therapies
Faustman DL, Davis M.
J Mol Med (Berl). 2009 Dec;87(12):1173-8.
doi: 10.1007/s00109-009-0516-6.
Epub 2009 Aug 21. Review.
PMID: 19693476
Selective Death Of Autoreactive T Cells In Human Diabetes By TNF Or TNF Receptor 2 Agonism
Ban L, Zhang J, Wang L, Kuhtreiber W, Burger D, Faustman DL.
Proc Natl Acad Sci U S A. 2008 Sep 9;105(36):13644-9.
doi: 10.1073/pnas.0803429105.
Epub 2008 Aug 28.
PMID: 18755894 Free PMC Article
Fetal Hox11 Expression Patterns Predict Defective Target Organs: A Novel Link Between Developmental Biology And Autoimmunity
Lonyai A, Kodama S, Burger D, Faustman DL.
Immunol Cell Biol. 2008 May-Jun;86(4):301-9.
doi: 10.1038/icb.2008.6.
Epub 2008 Feb 26.
PMID: 18301381 Free PMC Article
The Promise of Hox11+ Stem Cells Of The Spleen For Treating Autoimmune Diseases
Lonyai A, Kodama S, Burger D, Davis M, Faustman DL.
Horm Metab Res. 2008 Feb;40(2):137-46.
doi: 10.1055/s-2007-1022560. Review.
PMID: 18283632
Comment On Papers By Chong et al., Nishio et al., and Suri et al. On Diabetes Reversal In NOD Mice
Faustman DL, Tran SD, Kodama S, Lodde BM, Szalayova I, Key S, Toth ZE, Mezey E.
Science. 2006 Nov 24;314(5803):1243; author reply 1243.
PMID: 17124308