The benefits of clustering in TNF receptor superfamily signaling

Eva S. Vanamee and Denise L. Faustman

Frontiers in Immunology August 2023

Bacille Calmette Guerin (BCG) and prevention of types 1 and 2 diabetes: Results of two observational studies

Hans F. Dias, Yoshihiko Mochizuki, Willem M. Kühtreiber, Hiroyuki Takahashi, Hui Zheng, Denise L. Faustman

PLOS ONE January 2023

TNFR2 antagonistic antibody induces the death of tumor infiltrating CD4+Foxp3+ regulatory T cells

Tianzhen He,Yibo Chen, De Yang, Md Sahidu, Islam1, Chon‑Kit Chou, Jiarui Liu, Denise L. Faustman, Joost J. Oppenheim, Xin Chen

Cellular OncologyNovember 2022

BCG vaccinations drive epigenetic changes to the human T cell receptor: Restored expression n type 1 diabetes

Hiroyuki Takahashi, Willem M. Kühtreiber, Ryan C. Keefe, Amanda H. Lee, Anna Aristarkhova, Hans F. Dias, Nathan Ng, Kacie J. Nelson, Stephanie Bien, Danielle Scheffey, Denise L. Faustman

Science Advances November 2022

Multiple BCG vaccinations for prevention of COVID-19 and other infectious diseases in Type 1 diabetes

Denise L. Faustman, Amanda Lee, Emma R. Hostetter, Anna Aristarkhova, Nathan C. Ng, Gabriella F. Shpilsky, Lisa Tran, Grace Wolfe, Hiroyuki Takahashi, Hans F. Dias, Joan Braley, Hui Zheng, David A. Schoenfeld, Willem M. Kuhtreiber

Cell Reports Medicine August 2022

The Roles of TNFR2 Signaling in Cancer Cells and the Tumor Microenvironment and the Potency of TNFR2 Targeted Therapy

Hiroyuki Takahashi, Gumpei Yoshimatsu, and Denise Louise Faustman

American Diabetes Association Annual Scientific Sessions​ June 2022

2022 Update on the BCG Clinical Trial Programs in Advanced Type 1 Diabetes

W.M. Kühtreiber, H.F. Dias, E. Hostetter, A.H. Lee, N. Ng, G. Wolfe, A. Aristarkhova, J. Bradley, H. Zheng, & D.L Faustman

American Diabetes Association Annual Scientific Sessions​ June 2022

Underlying T Cell Receptor Methylation Defects in Type 1 Diabetes Associated with Quantitative Defects

H. Takahashi, W.M. Kühtreiber, A.H. Lee, A. Aristarkhova, H.F. Dias, N. Ng, S. Bien, D. Scheffey, & D.L Faustman

American Diabetes Association Annual Scientific Sessions​  June  2022

Signal Amplification in Highly Ordered Networks Is Driven by Geometry

Éva S. Vanamee, Gábor Lippner and Denise L. Faustman

Cells January 13, 2022

A TNFR2 antibody by countering immunosuppression cooperates with HMGN1 and R848 immune stimulants to inhibit murine colon cancer

Mengmeng Jiang, Jia Liu, De Yang, Debra Tross, Ping Li, Fengyang Chen, Md Masud Alam, Denise L. Faustman, Joost J. Oppenheim, Xin Chen

International Immunopharmacology  November 15  2021

Bacillus Calmette-Guerin ’s beneficial impact on glucose metabolism: Evidence for broad based applications

Gabriella F. Shpilsky, Hiroyuki Takahashi, Anna Aristarkhova, Michele Weil, Nathan Ng, Kacie J. Nelson, Amanda Lee, Hui Zheng, Willem M. Kuhtreiber, and Denise L. Faustman

iSciene  October 22  2021

BCG therapy is associated with long-term, durable induction of Treg signature genes by epigenetic modulation

Ryan C. Keefe, Hiroyuki Takahashi, Lisa Tran, Kacie Nelson, Nathan Ng,
Willem M. Kühtreiber & Denise L. Faustman

Scientific Reports   July 2021

Epigenetic changes related to glucose metabolism in type 1 diabetes after BCG vaccinations: A vital role for KDM2B

Hans F. Dias, Willem M. Kühtreiber, Kacie J. Nelson, Nathan C. Ng, Hui Zheng, Denise L. Faustman

Vacine  May  2021

A novel TNFR2 agonist antibody expands highly potent regulatory T cells

Heather Torrey, Willem M. Kühtreiber, Yoshiaki Okubo, Lisa Tran, Katherine Case, Hui Zheng, Eva Vanamee, Denise L. Faustman  

Science Signaling  December 8  2020

FOCIS 2020 Conference

October 28 – 31 2020

TNFR2 blockade alone or in combination with PD-1 blockade shows therapeutic efficacy in murine cancer models

Katherine Case, Lisa Tran, Michael Yang, Hui Zheng, Willem M. Kuhtreiber and Denise L. Faustman  

J Leukoc Biol May 2020

BCG Vaccinations Upregulate Myc, a Central Switch for Improved Glucose Metabolism in Diabetes

Willem M. Kuhtreiber, Hiroyuki Takahashi, Ryan C. Keefe, Yaerin Song, Lisa Tran, Trevor G. Luck,Gabriella Shpilsky, Louisa Moore, Sarah M. Sinton, Jessica C. Graham, and Denise L. Faustman

iScience May 22, 2020

Optimizing TNFR2 Antagonism for Immunotherapy with Tumor Microenvironment Specificity

Michael Yang, Lisa Tran, Heather Torrey, Yaerin Song, Haley Perkins, Katherine Case, Hui Zheng, Hiroyuki Takahashi, Willem M. Kuhtreiber, Denise L. Faustman  

Journal of Leukocyte Biology  March 2020

On the TRAIL of Better Therapies: Understanding TNFRSF Structure-Function

Éva S. Vanamee and Denise L. Faustman

Cells March 2020

BCG Therapy for Type 1 Diabetes: Restoration of Balanced Immunity and Metabolism

Willem M. Kühtreiber and Denise L. Faustman

Cell Press February 2019

Bridging the gap between vaccination with Bacille Calmette-Gue´ rin (BCG) and immunological tolerance: the cases of type 1 diabetes and multiple sclerosis

Giovanni Ristori, Denise Faustman, Giuseppe Matarese,
Silvia Romano and Marco Salvetti

CurrentOpinionImmunology  December 2018

Intrinsic TNFR2 signaling in T regulatory cells provides protection in CNS autoimmunity

Kamar-Sulu N. Atretkhany, Ilgiz A. Mufazalov, Josefine Dunst, Anna Kuchmiy, Violetta S. Gogoleva,David Andruszewski, Marina S. Drutskaya, Denise L. Faustman, Marius Schwabenland, Marco Prinz,Andrey A. Kruglov, Ari Waisman, and Sergei A. Nedospasov. 

PNAS  November 2018

Targeted killing of TNFR2-expressing tumor cells and Tregs by TNFR2 antagonistic antibodies in advanced Sézary syndrome

H Torrey, M Khodadoust, L Tran, D Baum, A Defusco, Y H Kim, D L Faustman

Nature Leukemia  October 24 2018

Long-term Reduction in Hyperglycemia in Advanced Type 1 Diabetes: The Value of Induced Aerobic Glycolysis with BCG Vaccinations

Willem M. Kühtreiber, Lisa Tran, Taesoo Kim, Michael Dybala, Brian Nguyen, Sara Plager, Daniel Huang, Sophie Janes, Audrey Defusco, Danielle Baum, Hui Zheng & Denise L. Faustman

npj Vaccines  June 21 2018

Structural Principles of Tumor Necrosis Factor Superfamily Signaling

Vanamee ÉS, Faustman DL. 

Sci Signal. 2018 Jan 2;11(511).

pii: eaao4910. doi: 10.1126/scisignal.aao4910. Review.

TNFR2: A Novel Target for Cancer Immunotherapy

Vanamee ÉS, Faustman DL. 

Trends Mol Med. 2017 Nov;23(11):1037-1046.

doi: 10.1016/j.molmed.2017.09.007.
Epub 2017 Oct 12. Review.
PMID: 29032004

TNF, TNF Inducers, and TNFR2 Agonists: A New Path to Type 1 Diabetes Treatment

Faustman DL. 

Diabetes Metab Res Rev. 2018 Jan;34(1).

doi: 10.1002/dmrr.2941.
Epub 2017 Sep 29. Review.
PMID: 28843039

Targeting TNFR2 with Antagonistic Antibodies Inhibits Proliferation of Ovarian Cancer Cells and Tumor-associated Tregs

Torrey H, Butterworth J, Mera T, Okubo Y, Wang L, Baum D, Defusco A, Plager S, Warden S, Huang D, Vanamee E, Foster R, Faustman DL. 

Sci Signal.2017 Jan 17;10(462).

pii: eaaf8608. doi: 10.1126/scisignal.aaf8608.
PMID: 28096513

Treg Activation Defect In Type 1 Diabetes: Correction With TNFR2 Agonism

Okubo Y, Torrey H, Butterworth J, Zheng H, Faustman DL.

Clin Transl Immunology. 2016 Jan 8;5(1):e56.

doi: 10.1038/cti.2015.43.
eCollection 2016 Jan.
PMID: 26900470 Free PMC Article

Strategic Internal Covalent Cross-linking of TNF Produces A Stable TNF Trimer with Improved TNFR2 Signaling

Ban L, Kuhtreiber W, Butterworth J, Okubo Y, Vanamee ÉS, Faustman DL.

Mol Cell Ther. 2015 Aug 12;3:7.

doi: 10.1186/s40591-015-0044-4.
eCollection 2015.

Low Levels of C-peptide Have Clinical Significance for Established Type 1 Diabetes

Kuhtreiber WM, Washer SL, Hsu E, Zhao M, Reinhold P 3rd, Burger D, Zheng H, Faustman DL.

Diabet Med. 2015 Oct;32(10):1346-53.

doi: 10.1111/dme.12850.
Epub 2015 Aug 16.
PMID: 26172028 Free PMC Article

Removal of Donor Human Leukocyte Antigen Class I Proteins With Papain: Translation for Possible Whole Organ Practices

Mera T, Faustman DL.
Transplantation. 2015 Apr;99(4):724-30.
doi: 10.1097/TP.0000000000000436.
PMID: 25340603

TNF Receptor 2 and Disease: Autoimmunity and Regenerative Medicine

Faustman DL, Davis M.
Front Immunol. 2013 Dec 23;4:478.
doi: 10.3389/fimmu.2013.00478.
PMID: 24391650 Free PMC Article

Homogeneous Expansion Of Human T-regulatory Cells Via Tumor Necrosis Factor Receptor 2

Okubo Y, Mera T, Wang L, Faustman DL.
Sci Rep. 2013 Nov 6;3:3153.
doi: 10.1038/srep03153.
PMID: 24193319 Free PMC Article 

Why Were We Wrong For So Long? The Pancreas Of Type 1 Diabetic Patients Commonly Functions for Decades

Faustman DL. Diabetologia.
2014 Jan;57(1):1-3.
doi: 10.1007/s00125-013-3104-9.
Epub 2013 Nov 5.
PMID: 24190583

Proof-of-concept, Randomized, Controlled Clinical Trial Of Bacillus-Calmette-Guerin For Treatment Of Long-term Type 1 Diabetes

Faustman DL, Wang L, Okubo Y, Burger D, Ban L, Man G, Zheng H, Schoenfeld D, Pompei R, Avruch J, Nathan DM.
PLoS One. 2012;7(8):e41756.
doi: 10.1371/journal.pone.0041756.
Epub 2012 Aug 8.
PMID: 22905105 Free PMC Article

Persistence of Prolonged C-peptide Production In Type 1 Diabetes As Measured With An Ultrasensitive C-peptide Assay

Wang L, Lovejoy NF, Faustman DL.
Diabetes Care. 2012 Mar;35(3):465-70.
doi: 10.2337/dc11-1236.
PMID: 22355018 Free PMC Article

Novel Automated Blood Separations Validate Whole Cell Biomarkers

Burger DE, Wang L, Ban L, Okubo Y, Kühtreiber WM, Leichliter AK, Faustman DL.
PLoS One. 2011;6(7):e22430.
doi: 10.1371/journal.pone.0022430. Epub 2011 Jul 22.
PMID: 21799852 Free PMC Article

Stem Cells In The Spleen: Therapeutic Potential For Sjogren’s Syndrome, Type I Diabetes, And Other Disorders

Faustman DL, Davis M.
Int J Biochem Cell Biol. 2010 Oct;42(10):1576-9.
doi: 10.1016/j.biocel.2010.06.012.
Epub 2010 Jun 18. Review.
PMID: 20601088 Free PMC Article

The Primacy Of CD8 T Lymphocytes In Type 1 Diabetes And Implications For Therapies

Faustman DL, Davis M.
J Mol Med (Berl). 2009 Dec;87(12):1173-8.
doi: 10.1007/s00109-009-0516-6.
Epub 2009 Aug 21. Review.
PMID: 19693476

Selective Death Of Autoreactive T Cells In Human Diabetes By TNF Or TNF Receptor 2 Agonism

Ban L, Zhang J, Wang L, Kuhtreiber W, Burger D, Faustman DL.
Proc Natl Acad Sci U S A. 2008 Sep 9;105(36):13644-9.
doi: 10.1073/pnas.0803429105.
Epub 2008 Aug 28.
PMID: 18755894 Free PMC Article

Fetal Hox11 Expression Patterns Predict Defective Target Organs: A Novel Link Between Developmental Biology And Autoimmunity

Lonyai A, Kodama S, Burger D, Faustman DL.
Immunol Cell Biol. 2008 May-Jun;86(4):301-9.
doi: 10.1038/icb.2008.6.
Epub 2008 Feb 26.
PMID: 18301381 Free PMC Article

The Promise of Hox11+ Stem Cells Of The Spleen For Treating Autoimmune Diseases

Lonyai A, Kodama S, Burger D, Davis M, Faustman DL.
Horm Metab Res. 2008 Feb;40(2):137-46.
doi: 10.1055/s-2007-1022560. Review.
PMID: 18283632

Comment On Papers By Chong et al., Nishio et al., and Suri et al. On Diabetes Reversal In NOD Mice

Faustman DL, Tran SD, Kodama S, Lodde BM, Szalayova I, Key S, Toth ZE, Mezey E.
Science. 2006 Nov 24;314(5803):1243; author reply 1243.
PMID: 17124308